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Attempts to neutralise basic fibroblast growth factor (BFGF) have met some success in blocking neovascularisation. The authors describe an oral protein vaccine based on human BFGF encapsulated poly(ε-caprolactone)εpoly(ethylene glycol)εpoly(ε-caprolactone) (PCEC) nanoparticles. The human BFGF encapsulated PCEC nanoparticles (BFGF/PCEC) were monodisperse with the mean diameter of 142εnm and can slow-released...
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