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Different methods for analyzing the sensitivity of the direct signal transduction pathway of receptor-induced apoptosis to parameter changes are presented. Apoptosis is a form of programmed cell death, removing unwanted cells within multicellular organisms to maintain a proper balance between cell reproduction and death. The results indicate the importance of controlling activated caspases by direct...
Bone is a dynamic living tissue that undergoes continuous adaptation of its mass and structure in response to mechanical and biological environment demands. Studies of bone adaptation have focused on metabolic or mechanical stimulus, but mathematical models of bone adaptation considering both, are not available by now. In this paper, we propose a mathematical model of bone adaptation during a remodeling...
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