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In article number 2001157, Fazheng Ren, Yuan Li, and co‐workers demonstrate an intestinal responsive delivery system for improving the viability of probiotics in gastrointestinal conditions using modified Konjac glucomannan. The delivered probiotics survive under gastric conditions and responsively release in the intestine. Then, disintegrated polysaccharides function as a bridge, promoting the adhesion...
The low survival rate in harsh stomach conditions and short retention in intestine of probiotics greatly limit their health benefits. To solve this problem, thiolated oxidized konjac glucomannan (sOKGM) microspheres is designed with pH responsive and mucoadhesive properties. First, an increased survival rate of probiotics by sOKGM microspheres encapsulation in simulated gastric fluid (SGF) is discovered...
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