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Silicon devices based on impedance measurements offer label-free and direct electrical detection when used to quantify the hybridization of DNA molecules. They show rapid, robust, and inexpensive measurement and compatibility with commercial microfabrication technology. The real-time measurement of the impedance does not require the use of labeling molecules attached to the target DNA in optical and...
This paper reports a novel electrical detection of label-free DNA by use of a MEMS electrostatic micro-switch. The electrostatic micro-switch detects the immobilization of probe oligonucleotides and their hybridization with target oligonucleotides using pull-in voltage shift in the micro-switch originated from negative charges of the oligonucleotides. A numerical simulation is analyzed to support...
This paper presents fully integrated label-free DNA recognition circuit based on capacitance measurement. A CMOS-based DNA sensor is implemented for the electrical detection of DNA hybridization. The proposed architecture detects the difference of capacitance through the integration of current mismatch of capacitance between reference electrodes functionalized with only single-stranded DNA and sensing...
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