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The immunopathogenesis of multisystem inflammatory syndrome (MIS‐C) in children that may follow exposure to SARS‐CoV‐2 is incompletely understood. Here, we studied SARS‐CoV‐2‐specific T cells in MIS‐C, Kawasaki disease (KD), and SARS‐CoV‐2 convalescent controls using peptide pools derived from SARS‐CoV‐2 spike or nonspike proteins, and common cold coronaviruses (CCC). Coordinated CD4+ and CD8+ SARS‐CoV‐2‐specific...
We characterized a novel population of tolerogenic myeloid dendritic cells (tmDCs) defined as CD11c+CD11b+CD14+CD4+ and immunoglobulin‐like transcript receptor (ILT)‐4+ that are significantly more abundant in the circulation of infants and young children than in adults. TmDCs secrete the immunosuppressive lymphokine interleukin (IL)‐10 when stimulated with the heavy constant region of immunoglobulins...
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