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Nano Cell Cycle Checkpoint Inhibitors
In article number 2300736, Daishun Ling, Fangyuan Li, and co‐workers demonstrate that ultra‐small iron oxide nanoparticles (IONPs) can serve as a selective nano cell cycle checkpoint inhibitor (NCCI) to catalyze the intracellular H2O2 into abundant ·OH, cleave heat shock protein 90 (Hsp90), and thus induce the degradation of the client protein ATR/CHK1, leading...
Cell cycle checkpoint activation promotes DNA damage repair, which is highly associated with the chemoresistance of various cancers including acute myeloid leukemia (AML). Selective cell cycle checkpoint inhibitors are strongly demanded to overcome chemoresistance, but remain unexplored. A selective nano cell cycle checkpoint inhibitor (NCCI: citric acid capped ultra‐small iron oxide nanoparticles)...