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Tumor vasculature and cancer stem cells (CSCs) accelerate the development of metastatic renal cancer. Dual inhibition of vascular endothelium and CSCs is still a challenge due to their different pathological features. Herein, a transformable dual‐inhibition system (TDS) based on a self‐assembly peptide is proposed to construct nanofibrous barriers on the cell membrane in situ, which contributes to...
In article number 2004548, Lei Wang, Ziqi Wang, Hao Wang, Wanhai Xu, and co‐workers propose a transformable dual‐inhibition system (TDS) based on a self‐assembly peptide to reduce metastasis of renal cancer via the inhibition of neovascular endothelial cells and cancer stem cells simultaneously. The TDS has great value in suppressing renal cancer metastasis. Additionally, this newly developed TDS...
Objectives
It has been accounted that miR‐664a‐3p has different functions in several malignancies; however, the precise role and underlying mechanism in gastric cancer have not been elucidated. Our study aims to explore the function of miR‐664a‐3p on the progression of gastric cancer (GC).
Methods
qRT‐PCR was applied to detect the expression of miR‐664a‐3p in GC tissues and cells. The functions...
BACKGROUNDThe Epstein‐Barr virus (EBV)‐encoded EB nuclear antigen 1 (EBNA1) protein is required for maintenance and transmission of the viral episome in EBV‐infected cells. The objective of this study was to investigate the role of EBNA1 protein in nasopharyngeal carcinoma (NPC).
METHODSTissue samples from 48 patients with NPC and 12 patients with chronic nasopharyngitis were subjected to immunohistochemical...
BACKGROUND:PIWI protein family was found to play an important role in stem cell self‐renewal. Overexpression of HIWI, the human homolog of PIWI family proteins, was found in several solid tumors, although the role of HIWI in hepatocellular carcinoma (HCC) and its prognostic value remain unclear.
METHODS:HIWI expression was measured in stepwise metastatic HCC cell lines (HCCLM3, MHCC97H, MHCC97L,...
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