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In order to delineate the influence of mechanical unloading on the formation and resorption of trabecular and cortical bone, the effects of mechanical unloading on the volume, structure, and turnover of hindlimbs were examined using tail-suspended rapidly growing rats. In addition, to clarify the mechanism of how mechanical stimulation affects bone formation, the influence of reloading on the messenger...
Although skeletal unloading causes a rapid loss of bone, the precise mechanism whereby mechanical unloading causes bone loss is as yet unclear. Using a tail suspension model in rats, we have previously shown that mechanical unloading of hind limbs causes a rapid increase in bone resorption at trabecular bone areas, which is followed by a sustained reduction in bone formation mainly at cortical bone...
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