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Aims
We are studying the dialogue between β‐cells and the immune system in type 1 diabetes and have identified a cell surface receptor, signal regulatory protein‐alpha (SIRPα) as an important component in the regulation of β‐cell survival. SIRPα interacts with another protein, CD47, to mediate signalling. In the present work, we have studied the expression and role of CD47 in human islet cells in...
Type 1 diabetes affects increasingly large numbers of people globally (including at least half a million children under the age of 14 years) and it remains an illness with life‐long and often devastating consequences. It is surprising, therefore, that the underlying aetiology of Type 1 diabetes remains poorly understood. This is largely because the cellular and molecular processes leading to the loss...
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