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We have shown that there is a strong dependence of the local wall shear stress (WSS) distribution on the cellular shape factors and the cellular alignment. Using three dimensional (3D) computational fluid mechanical (CFM) models, we found the complex distribution of WSS on the endothelial cells under actual culture conditions as well as under the flow conditions on the arteriolar wall. In the present...
We showed that spatial (three dimensional) as well as temporary wall shear stress (WSS) distribution on the wall in arteries of various normal and pathological configuration is completely different from two dimensional steady estimation and this difference is crucially responsible for the initiation, localization, and the development of arterial diseases, such as atherosclerosis. Though the importance...
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