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BACKGROUNDIncreased smooth muscle tone is a significant component of benign prostatic hyperplasia, the onset of which correlates with age and declining serum testosterone levels. This study investigates the effects of androgens on key regulators of smooth muscle tone: intracellular calcium ([Ca2+]i) and cyclic adenosine monophosphate (cAMP) in human cultured prostatic stromal cells (HCPSC).
METHODSHCPSC...
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