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Insulin‐like growth factor binding protein 2 (IGFBP2) overexpression is common in high‐grade glioma and is both a strong biomarker of aggressive behaviour and a well‐documented prognostic factor. IGFBP2 is a member of the secreted IGFBP family that functions by interacting with circulating IGFs to modulate IGF‐mediated signalling. This traditional view of IGFBP2 activities has been challenged by the...
Fifty-seven spontaneous canine gliomas were histologically classified and graded using the latest World Health Organization (WHO 2007) criteria for classification of human gliomas. A total of 19 canine astrocytomas were classified as follows: grade IV (GBM) n = 7; grade III n = 5; and grade II, n = 7. Thirty-eight oligodendrogliomas were classified as either grade III (anaplastic) n = 35 or low grade...
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