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The expression of dopamine, dopamine receptors and dopamine active transporters in peripheral lymphoid tissues and lymphocytes suggest that increased dopaminergic activity induced by cocaine may be involved in regulation of the distribution of lymphocyte subsets in the spleen. Adult male Wistar rats implanted with jugular vein catheter received cocaine hydrochloride (3 × 5 mg/kg/ml, i.v., at 30 min...
Cannabidiol (CBD) is a major non-psychotropic constituent of Cannabis. The endocannabinoid system, which can be modulated by administration of CBD, is known to play an important role in control of food intake and energy balance. In recent years, numerous studies have revealed various pharmacological effects of CBD such as neuroprotective, analgetic, anxiolytic, antipsychotic and anti-inflammatory...
Cannabidiol (CBD) is a major non-psychotropic compound derived from Cannabis that has wide therapeutic potential. In our previous studies we observed decreased body weight gain in rapidly growing rats (10 weeks of age at the start of study) treated with CBD for 14 consecutive days. The present study aimed to evaluate the effects of repeated CBD administration on body weight gain, food intake and accumulation...
Cannabidiol (CBD) is a major non-psychotropic compound of cannabis that has been reported to exert neuroprotective, antipsychotic and anxiolytic effects. CBD has promising anti-inflammatory properities, but despite therapeutic potential its mechanisms of action remain poorly understood. Our previous study revealed decrease in number of lymphocytes B and T in peripheral blood following repeated CBD...
Cocaine use has been associated with the increased risk for HIV and HCV infection in humans. The addicts have faster progression of HIV infection and increased incidence of AIDS suggesting that cocaine use results in a specifi c functional impairment of the immune system. Present study aimed to evaluate lymphocyte subsets number and distribution in peripheral blood after acute series of intravenous...
Cannabidiol (CBD), the major non-psychoactive compound of Cannabis has been reported to display neuroprotective, anti-infl ammatory, and anti-tumor actions. Despite growing interest in pharmacological effects of CBD, there is no data concerned with the effects of CBD on body weight, food intake or metabolism. The present study examined whether CBD administration affects body weight, during 13 days...
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