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The liver is a multifunctional organ that has important roles such as metabolism, synthesis, and detoxification. Enhanced hepatocyte apoptosis and impaired liver regeneration are the most common liver disorders in acute liver failure. Hepatocyte apoptosis also emerges as a fundamental component of chronic liver diseases. Liver tissue fibrosis is triggered by hepatocyte apoptosis, and the excess fibrosis...
Inhibition of the transcription factor nuclear factor kappa B (NFκB) induces marked hepatocyte apoptosis and liver dysfunction after partial hepatectomy (PH) in rats. Hepatocyte apoptosis may be due to direct inhibition of NFκB-induced hepatocyte survival genes or due to indirect increased signaling through the stress-activated protein kinase pathway (SAPK), resulting in increased c-Jun. c-Jun, an...
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