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The transmembrane 6 superfamily member 2 (TM6SF2) loss‐of‐function variant rs58542926 is a genetic risk factor for nonalcoholic fatty liver disease and progression to fibrosis but is paradoxically associated with lower levels of hepatically derived triglyceride‐rich lipoproteins. TM6SF2 is expressed predominantly in liver and small intestine, sites for triglyceride‐rich lipoprotein biogenesis and...
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