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In both human and animal mammals, the pacemaker of the heart, the sinoatrial node (SA node), deteriorates with age. The main features of the aged SA nodes are a slow pacemaking rate and possible SA node-atrium conduction exit block or arrest of SA node pacemaking (i.e., termination of the SA node pacemaker activity). The mechanisms underlying the age-related dysfunction of the heart are unclear. In...
Down-regulation of Kir2.1 channel reduces the inward-rectifier potassium current (iK1), and transforms excitable ventricular myocytes to pacemaker cells. This provides a possible bio-technique to induce a biological pacemaker, as an alternative to an implantable electronic pacemaker. However there are two fundamental issues: (i) the stability of the pacemaker activity; (ii) the critical size of the...
Atrial arrhythmias (flutter and fibrillation) are characterised by rapid and irregular activation of atrium. There are two possible mechanisms: abnormal spontaneous electrical activity of ectopic foci and multiple reentrant wavelets. In this study, we developed a biophysically detailed computer model of virtual human atrium to study the interaction between the two major arrhythmic origins. Depending...
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