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Disruption of neural signaling in the ventromedial nucleus (VMN) of rats by microinjection of the neurotoxin colchicine (COL) results in transient hyperphagia accompanied by enhanced weight gain. We tested the hypothesis that release of neuropeptide Y (NPY), a potent orexigenic signal is augmented within the paraventricular nucleus (PVN) of COL-treated hyperphagic rats. Adult male rats were microinjected...
Recent pharmacological and morphological studies have raised the likelihood of a regulatory link beteen the neuropeptide Y (NPY) and β-endorphin ( β-END) networks in the hypothalamus. To evaluate this link we have examined the effects of NPY administration on the in vivo release of β-END by push-pull perfusion of the basal hypothalamus. Results showed that centrally injected NPY stimulated the in...
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