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Recent pharmacological and morphological studies have raised the likelihood of a regulatory link beteen the neuropeptide Y (NPY) and β-endorphin ( β-END) networks in the hypothalamus. To evaluate this link we have examined the effects of NPY administration on the in vivo release of β-END by push-pull perfusion of the basal hypothalamus. Results showed that centrally injected NPY stimulated the in...
Agmatine, a clonidine displacing substance and imidazoline receptor agonist, was recently isolated from bovine brain and shown to be present in the rat hypothalamus. Since clonidine can stimulate the release of pituitary luteinizing hormone (LH), we tested the hypothesis that agmatine may similarly act in the rat to stimulate the hypothalamic luteinizing hormone-releasing hormone (LHRH)-pituitary...
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