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New concepts on cancer- and metastasis-initiating cells suggest that these immature cells endowed with a high self-renewal potential and aberrant multilineage differentiation ability can provide critical functions for tumor initiation, metastases at distant tissues and organs, treatment resistance and disease relapse. The malignant transformation of multipotent tissue-resident adult stem/progenitor...
Complex signaling cross‐talks between different growth factor cascades orchestrate the primary brain cancer development. Among the frequent deregulated oncogenic pathways, the ligand‐activated wild‐type epidermal growth factor receptor (EGFR), constitutively activated EGFRvIII mutant and sonic hedgehog pathways have attracted much attention because of their pivotal roles in pediatric medulloblastomas...
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