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The HLA class II isotype and allelic restrictions of peptide recognition were analyzed with T cells from a DRB1 1501/DRB1 0901 heterozygous donor. Nineteen T cell clones, all directed against the single mycobacterial epitope p21-40 were tested with HLA homozygous lymphoblastoid cell lines as antigen-presenting cells. The most striking finding has been, that several DR isotype restricted clones recognized...
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