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COVER PHOTOGRAPH: Confocal image of live 36 hpf double transgenic appais22Gt; Tg(flk1:moesin‐gfp)is1 embryo. The image shows accumulation of appaRFP fusion proteins specifically at the veinous vessels in the head and anterior region of the trunk, including the midcerebral and common cardinal veins. Arteries and veins are visualized by expression of moesin:GFP throughout all endothelial cells of the...
Background: The single spanning transmembrane amyloid precursor protein (APP) and its proteolytic product, amyloid‐beta (Aβ) peptide, have been intensely studied due to their role in the pathogenesis of Alzheimer's disease. However, the biological role of the secreted ectodomain of APP, which is also generated by proteolytic cleavage, is less well understood. Here, we report Tol2 red fluorescent protein...
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