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Although tert-butyl hydroperoxide (t-BHP) is commonly used to induce oxidative stress, little is known about the time- or dose-dependence of its oxidative effects. In this study, we examined hepatotoxicity and oxidative stress in male rats at various times (0–24h) after t-BHP (0, 0.2, 0.5, 1 or 3mmol/kg, ip) treatment. Serum hepatotoxicity parameters were increased from 2h following 1mmol/kg t-BHP...
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