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A series of tetrahydroisoquinoline derivatives were prepared and their antitumor activity was studied against several human carcinoma cell lines, including Ketr3, BEL‐7402, BGC‐823, KB, HCT‐8, MCF‐7, HeLa, A2780, A549, and HT‐1080. Compound 20, an analog of phthalascidin 650, exhibited good broad‐spectrum antitumor activity in vitro. However, compounds 19 and 21, in which the side chains at C‐22 are...
To investigate the antitumor activity of tumor lysate-pulsed dendritic cells vaccine in RM-1 prostate cancer mice model with the survival time of mice calculated and the tumor size measured in DC vaccine therapy. C57BL/6 mice were immunized on the dorsal flank by s.c. inoculation of Lysate-DC, ova-DC, and non-DC on day −7. On day 0, 2×10 6 cells of RM-1 tumor cells (H-2 b ) were...
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