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INTRODUCTION: Advanced paternal age (APA) is a risk factor for conceiving children with autism spectrum disorders. Social deficits, altered communication and repetitive behaviors are key diagnostic symptoms of autism. AIM(S): In this study we used a mouse model to investigate the effects of APA on offspring communicative behaviors - ultrasound vocalization (USV). METHOD(S): 4–5 month old Swiss males...
BACKGROUND AND AIMS: Advanced Paternal Age (APA) has been shown to be a significant risk factor for neurodevelopmental psychiatric disorders, such as autism. We have recently shown that mice conceived by old fathers display behavioral abnormalities which resemble key diagnostic symptoms of human autism, including social deficits, communicative defects and repetitive behaviors. The aim of the present...
BACKGROUND AND AIMS: We investigated the number of proliferating cells in the dentate gyrus of the hippocampus and anxietylike behavior of mice after damage to the projections from the locus coeruleus as a result of a single administration (50 mg/kg) of DSP-4 that is a selective neurotoxin of central and peripheral noradrenergic neurons. METHODS: Adult male Swiss mice were divided into 2 groups whose...
BACKGROUND AND AIMS: Biomarkers are biological indicators that permit qualitative study and quantitative evaluation of various conditions, phenomena or biological features. In modern medicine biomarkers are used for precise and relatively easy diagnosis of chronic diseases, and the assessment of likelihood of their occurrence. Nowadays, it is intensively explored research area for new therapies and...
Transcriptome profiling of chronic social stress (CSS) effects on the brain revealed changes in expression of many genes responsible for alterations of structure and function of the central nervous system. However, there is still little information on dynamics of gene expression in the brain during chronic stress. The aim of the study was to investigate the time course of mouse hippocampal transcriptome...
Alcoholism is a complex disease with hereditary influence. To elucidate genetic contribution, microarrays were used to probe for differences in gene expression in limbic system structures in strains of rats selected for several generations for alcohol preference: Warsaw High Preferring (WHP) strain and Warsaw Low Preferring (WLP) strain. Microarray analyses of medial prefrontal cortex (mPFC), hippocampus...
We assesed the effectiveness of coping with stress during a 30 hours driving course by people with different levels of stress. Volunteers aged 18–30 took participated: 8 women and 7 men in the control group, and 9 women and 9 men preparing for the exam. Before the start of the course all participants took the Coping Inventory for Stressful Situations (CISS). Saliva samples to measure cortisol were...
Training of dogs to distinguish individual human scent has no well-established scientific basis. The aim of the study was to evaluate the progress made over three consecutive training phases and to compare the training results with those of the working phase. Six naive German Shepherd dogs (4 males and 2 females) were trained to match one target human scent, placed randomly in a lineup of five other...
Investigated were changes in selected redox parameters – vitamin C, malondialdehyde (MDA) and glutathione (GSH) content of goat blood plasma – as markers of oxidative stress after per os administration the N-acetylcysteine (NAC). Used were 20 Polish White Improved goats, selected from the flock of 60 animals. Within the selected goats distinguished were four groups according to somatic cell counts...
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