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A series of new 1-aryl-3-benzazepine derivatives containing an arylpiperazinyl function as the N3 substituent were synthesized by combining a D 1 receptor agonistic pharmacophore and a 5-HT 1A receptor pharmacophore through Click reaction. Interestingly, these compounds generally do not have good binding affinity at the D 1 receptor, but most compounds are potent at both D...
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