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Background
Chemokines are involved not only in regulating leucocyte recruitment, but also in other activities. However, functions other than cell recruitment remain poorly understood. We have already shown that the production of CC chemokine ligand (CCL)17 and CCL22 by antigen‐stimulated naïve CD4+ T cells was higher in asthmatic patients than in healthy controls. However, the role of these chemokines...
Background and objectiveSynthesis of cysteinyl leukotrienes (cys‐LT) is thought to cause inflammatory disorders such as bronchial asthma and allergic rhinitis. Recent reports have suggested that leukotriene C4 (LTC4) is an important regulator of pulmonary fibrosis. This study examined the effect of LTC4 in LTC4 synthase‐overexpressed transgenic mice with bleomycin‐induced pulmonary fibrosis. The function...
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