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The diagnosis of atherosclerotic plaque based on time-resolved laser-induced fluorescence spectroscopy and the relationship of the endogenous fluorophores in lesions with the wavelength-resolved and especially the time-resolved data were investigated. The major fluorophores in arterial tissues are elastin and collagen (type I and III), and lipid components such as free cholesterol, cholesterol esters...
Fluorescence/Raman scattering in a liquid-core optical fiber waveguide based on hollow-core photonic-crystal fibers was demonstrated. 10 times of signal enhancement in a 6-cm long fiber was achieved. Different PCFs showed different enhancement factors.
Styryl dyes have been among the most widely used probes for mapping membrane potential changes in excitable cells. However, their utility has been somewhat limited because their excitation wavelengths have been restricted to the 450–550nm range. Longer wavelength probes can minimize interference from endogenous chromophores and, because of decreased light scattering, improve recording from deep within...
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