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In this study, enhancement of transbuccal permeation of morphine sulfate was studied in the presence of sodium glycodeoxycholate (GDC). The permeability of the bovine buccal mucosa to morphine sulfate was determined in vitro in the absence and presence of GDC at 10 mM and 100 mM concentrations. Light and electron microscopy studies were performed to determine the histological and ultrastructural changes...
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