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P2Y 1 and P2Y 12 receptors are expressed in platelet membranes and are involved in ADP-induced platelet aggregation. Genetic polymorphisms of P2Y 1 and P2Y 12 play a major role in the variation of ADP-induced platelet aggregation and in response in antiplatelet therapy.To evaluate the allele frequencies of P2Y 1 and P2Y 12 genetic polymorphisms in a...
The present study analyzed the polymorphisms of DNA repair genes and their impact on the survival of 240 patients with early breast cancer. The genomic DNA was extracted from paraffin-embedded tumor-free tissue or blood, and thirteen polymorphisms in 12 DNA repair genes were determined using the Sequenom Mass array system. Among the target polymorphisms, VARS2 rs2074511 and POLE rs5744857 were found...
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