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Tissue mechanical anisotropy has been shown to be diagnostically relevant in numerous clinical applications. Anisotropy can be assessed using acoustic radiation force-based techniques, including Acoustic Radiation Force Impulse (ARFI) and Viscoelastic Response (VisR) ultrasound. In this work, ARFI peak displacement (PD), as well as VisR relative elasticity (RE) and relative viscosity (RV), were implemented...
While skeletal muscle is often assumed to be structurally transversely isotropic (TI), its mechanical anisotropy is not well characterized in vivo. VisR ultrasound, a technique that provides information about the viscoelastic mechanical response of tissue, can be used for such in vivo characterization. Specifically, VisR-derived Relative Elasticity (RE) provides directionally dependent information...
Previous work has shown that the degree of anisotropy in tissue can be assessed using Acoustic Radiation Force Impulse (ARFI) imaging performed with a geometrically asymmetric excitation. In this work, we investigate the clinical relevance of mechanical anisotropy in Duchenne muscular dystrophy (DMD). Anisotropy assessment was performed using relative elasticity (RE) and relative viscosity (RV) parameters...
Duchenne muscular dystrophy (DMD) is a genetic disorder that causes progressive muscle degeneration involving necrosis and inflammation, with subsequent replacement of muscle fibers by fibrosis and fatty tissue. These compositional changes underlie mechanical property alterations in affected muscles, which may be assessed using Viscoelastic Response (VisR) ultrasound. We hypothesize that VisR will...
Viscoelastic Response (VisR) imaging is an acoustic radiation force (ARF)-based ultrasonic technique for estimating the viscoelastic properties of tissue. It has been proposed as a method for monitoring degeneration in the skeletal muscles of boys with Duchenne muscular dystrophy (DMD). DMD causes progressive inflammation, necrosis, fibrosis and fatty deposition in muscle, all of which will alter...
Dystroglycan is an integral member of the skeletal muscle dystrophin glycoprotein complex, which links dystrophin to proteins in the extracellular matrix. Recently, a group of human muscular dystrophy disorders have been demonstrated to result from defective glycosylation of the α-dystroglycan subunit. Genetic studies of these diseases have identified six genes that encode proteins required for the...
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