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Multichannel Sonocatalysis Amplifiers
In article number 2303869, Junjie Liu, Kun Zhang, Yan Liu, and co‐workers engineer multichannel sonocatalysis amplifiers to target tumor vulnerability, disrupt Ca2+/redox homeostasis, reprogramme mitochondrial energy and substance metabolism, and attenuate IDH1‐mutated tumor adaptation to disarm robust tumor plasticity and IHD‐mutation‐induced tolerance to sonocatalysis...
Tumor adaptation‐originated tumor tolerance that compensatory mechanisms (e.g., isocitrate dehydrogenase (IDH) mutation) jointly shape is the dominant obstacle of ROS therapy. Currently, targeting a single pathway fails to fundamentally reverse the complex milieu and diminish tumor adaptation. Herein, a multichannel sonocatalysis amplifier is engineered via one‐pot gas diffusion method to attenuate...