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BackgroundAllergen‐specific IgGs are known to inhibit IgE‐mediated mast cell degranulation by two mechanisms, allergen‐neutralization and engagement of the inhibitory FcγRIIB recruiting the phosphatase SHIP‐1. Here we unravel an additional mechanism of IgG‐mediated mast cell desensitization in mice: down‐regulation of allergen‐specific IgE.
MethodsMast cells were loaded in vitro and in vivo with...
BackgroundThere are conflicting study results regarding the association of exposure to visible mould and fungal components in house dust with respiratory and allergic diseases in children. It has been suggested that functional polymorphisms of the GSTP1 gene may influence the risk for allergic disorders through an impaired defence against oxidant injury.
MethodsWe examined in six birth cohorts of...
BackgroundVitamin D levels are known to be associated with atopic disease development; however, existing data are controversial. The aim of this study was to investigate whether corresponding maternal and cord blood vitamin D levels are associated with atopic outcomes in early infancy.
MethodsWithin the LINA cohort study (Lifestyle and environmental factors and their Influence on Newborns Allergy...
Background:Regulatory T cells (Tregs) with stable FOXP3 expression are characterized by a specific demethylated region in the FOXP3 gene (Treg‐specific demethylated region, TSDR). The aim of this study was to analyse the influence of prenatal factors on cord blood Treg numbers, as detected by changes in the TSDR demethylation, and the subsequent risk for allergic diseases.
Methods:Analyses were performed...
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