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BF2.649, a high affinity and selective non-imidazole histamine H 3 -receptor antagonist/inverse agonist, was found to easily enter the brain after oral administration to mice: it displayed a ratio of brain/plasma levels of about 25 when considering either C max or AUC values. At low oral doses (2.5–20mg/kg), it elicited in mice a dose-dependent wakening effect accompanied with a shift...
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