Search results for: Wen-Chun Liu

Items from 1 to 20 out of 42 results

article

Evolution of estimated glomerular filtration rate in human immunodeficiency virus and hepatitis C virus‐coinfected patients receiving sofosbuvir‐based direct‐acting antivirals and antiretroviral therapy

Chen‐Hua Liu, Hsin‐Yun Sun, Szu‐Min Hsieh, Wen‐Chun Liu, more

Journal of Viral Hepatitis > 28 > 6 > 887 - 896

The nephrotoxicity of sofosbuvir (SOF) on human immunodeficiency virus and hepatitis C virus (HIV/HCV)‐coinfected patients receiving antiretroviral therapy (ART) remains controversial. We prospectively compared the estimated glomerular filtration rate (eGFR) changes in 167 patients receiving SOF‐based direct‐acting antivirals (DAAs) who also received tenofovir disoproxil fumarate (TFV)‐based (n = 116)...

article

Hepatitis E Virus Infections Among Human Immunodeficiency Virus–Positive Individuals During an Outbreak of Acute Hepatitis A in Taiwan

Kuan‐Yin Lin, Pi‐Han Lin, Hsin‐Yun Sun, Yi‐Ting Chen, more

Hepatology > 70 > 6 > 1892 - 1902

Hepatitis A virus (HAV) and hepatitis E virus (HEV) share the similar fecal‐oral transmission route. During an outbreak of sexually transmitted acute hepatitis A among men who have sex with men (MSM) worldwide between 2015 and 2017, we investigated the possibility of sexual transmission and related morbidity of HEV infection among human immunodeficiency virus (HIV)‐positive patients. From March 1,...

article

HCV reinfections after viral clearance among HIV‐positive patients with recent HCV infection in Taiwan

Miao‐Hui Huang, Sui‐Yuan Chang, Chen‐Hua Liu, Aristine Cheng, more

Liver International > 39 > 10 > 1860 - 1867

Background Higher rates of hepatitis C virus (HCV) reinfection after viral clearance have been well described among HIV‐positive men who have sex with men (MSM) in Europe. The epidemiology of HCV reinfection, however, has rarely been investigated among HIV‐positive patients in Asia‐Pacific region. Methods We retrospectively identified HIV‐positive patients with recent HCV infection who had cleared...

article

Long-term virological and serologic responses of chronic hepatitis B virus infection to tenofovir disoproxil fumarate-containing regimens in patients with HIV and hepatitis B coinfection

Yu-Shan Huang, Hsin-Yun Sun, Sui-Yuan Chang, Yu-Chung Chuang, more

Hepatology International > 2019 > 13 > 4 > 431-439

Background Data regarding the durability of HBV viral suppression with combination antiretroviral therapy (cART) containing tenofovir disoproxil fumarate (TDF) combined with lamivudine (3TC) or emtricitabine (FTC) in HIV/HBV-coinfected patients are scarce in hyperendemic areas of chronic HBV infection. Methods Between 2004 and 2016, HIV/HBV-coinfected Taiwanese with available baseline HBV DNA load...

article

Glycan‐masking hemagglutinin antigens from stable CHO cell clones for H5N1 avian influenza vaccine development

Ting‐Hsuan Chen, Wen‐Chun Liu, Chia‐Ying Lin, Chia‐Chyi Liu, more

Biotechnology and Bioengineering > 116 > 3 > 598 - 609

Refocusing of B‐cell responses can be achieved by preserving the overall fold of the antigen structure but selectively mutating the undesired antigenic sites with additional N‐linked glycosylation motifs for glycan masking the vaccine antigen. We previously reported that glycan‐masking recombinant H5 hemagglutinin (rH5HA) antigens on residues 83, 127, and 138 (g127 + g138 or g83 + g127 + 138 rH5HA)...

article

Serological responses to revaccination against HBV in HIV‐positive patients born in the era of nationwide neonatal HBV vaccination

Yi‐Chia Huang, Szu‐Min Hsieh, Wang‐Huei Sheng, Yu‐Shan Huang, more

Liver International > 38 > 11 > 1920 - 1929

Background Serological responses to revaccination against hepatitis B virus (HBV) are unclear in HIV‐positive adults who had undergone neonatal HBV vaccination and whose antibodies against HBV had waned in the era of combination antiretroviral therapy (cART). Methods Between 2000 and 2017, 666 HIV‐positive men who have sex with men (MSM) who were born after 1986, when nationwide neonatal HBV vaccination...

article

Serological responses to revaccination with hepatitis A virus (HAV) vaccines among HIV‐positive individuals whose anti‐HAV antibody waned after primary vaccination

Guan‐Jhou Chen, Hsin‐Yun Sun, Kuan‐Yin Lin, Aristine Cheng, more

Liver International > 38 > 7 > 1198 - 1205

Background Among HIV‐positive individuals, seroprotection for hepatitis A virus (HAV) following primary vaccination may wane with time. However, seroresponses to HAV revaccination are rarely investigated among HIV‐positive patients who have lost protective antibodies after primary vaccination. Methods During the outbreak of acute hepatitis A in Taiwan after June 2015, HAV‐seronegative, HIV‐positive...

article

Applications of next-generation sequencing analysis for the detection of hepatocellular carcinoma-associated hepatitis B virus mutations

I-Chin Wu, Wen-Chun Liu, Ting-Tsung Chang

Journal of Biomedical Science > 2018 > 25 > 1 > 1-12

Background Next-generation sequencing (NGS) is a powerful and high-throughput method for the detection of viral mutations. This article provides a brief overview about optimization of NGS analysis for hepatocellular carcinoma (HCC)-associated hepatitis B virus (HBV) mutations, and hepatocarcinogenesis of relevant mutations. Main body For the application of NGS analysis in the genome of HBV, four...

article

Incidence of acute hepatitis A among HIV‐positive patients during an outbreak among MSM in Taiwan: Impact of HAV vaccination

Guan‐Jhou Chen, Kuan‐Yin Lin, Hsin‐Yun Sun, Wang‐Huei Sheng, more

Liver International > 38 > 4 > 594 - 601

Background An unprecedented outbreak of acute hepatitis A has occurred among MSM in Taiwan since June 2015. We aimed to describe the seroepidemiology of HAV infection and to investigate the relationship between HAV vaccination and the incidence of acute hepatitis A among HIV‐positive patients at the largest designated hospital for HIV care during the outbreak. Methods Between 2012 and 2016, the...

article

Treatment response to unboosted atazanavir in combination with tenofovir disoproxil fumarate and lamivudine in human immunodeficiency virus-1-infected patients who have achieved virological suppression: A therapeutic drug monitoring and pharmacogenetic study

Mao-Song Tsai, Sui-Yuan Chang, Shu-Wen Lin, Ching-Hua Kuo, more

Journal of Microbiology, Immunology and Infection > 2017 > 50 > 6 > 789-797

Treatment response to switch regimens containing unboosted atazanavir and tenofovir disoproxil fumarate (TDF)/lamivudine guided by therapeutic drug monitoring in human immunodeficiency virus-infected patients is rarely investigated.Consecutive patients with plasma human immunodeficiency virus RNA load < 200 copies/mL switching to unboosted atazanavir plus zidovudine–lamivudine (coformulated), abacavir–lamivudine...

article

Detecting exact breakpoints of deletions with diversity in hepatitis B viral genomic DNA from next-generation sequencing data

Ji-Hong Cheng, Wen-Chun Liu, Ting-Tsung Chang, Sun-Yuan Hsieh, more

Methods > 2017 > 129 > C > 24-32

Many studies have suggested that deletions of Hepatitis B Viral (HBV) are associated with the development of progressive liver diseases, even ultimately resulting in hepatocellular carcinoma (HCC). Among the methods for detecting deletions from next-generation sequencing (NGS) data, few methods considered the characteristics of virus, such as high evolution rates and high divergence among the different...

article

Hepatocellular carcinoma‐associated single‐nucleotide variants and deletions identified by the use of genome‐wide high‐throughput analysis of hepatitis B virus

Wen‐Chun Liu, I‐Chin Wu, Yen‐Chien Lee, Chih‐Peng Lin, more

The Journal of Pathology > 243 > 2 > 176 - 192

This study investigated hepatitis B virus (HBV) single‐nucleotide variants (SNVs) and deletion mutations linked with hepatocellular carcinoma (HCC). Ninety‐three HCC patients and 108 non‐HCC patients were enrolled for HBV genome‐wide next‐generation sequencing (NGS) analysis. A systematic literature review and a meta‐analysis were performed to validate NGS‐defined HCC‐associated SNVs and deletions...

article

d:x reflectance measurement for curved surface with integrating sphere

Hsueh‐Ling Yu, Richard Young, Wen‐Chun Liu, Chin‐Chai Hsiao

Journal of the Society for Information Display > 25 > 6 > 356 - 365

Ambient contrast ratio (ACR) is a useful parameter to evaluate the quality of displays when used under diffuse lighting conditions. The methodology recommended by most documentary standards calculates the ACR of the display from d:x reflectance. Reflectance measurement of flat surfaces typically employs an integrating sphere and a flat white reference plate. However, the shape difference between the...

article

Willingness of human immunodeficiency virus‐positive patients to donate their organs for transplantation in Taiwan: a cross‐sectional questionnaire survey

Yi‐Chieh Lee, Chien‐Ching Hung, Aristine Cheng, Wen‐Chun Liu, more

Transplant Infectious Disease > 18 > 6 > 856 - 861

Background With the introduction of combination antiretroviral therapy (cART) that has significantly improved survival, human immunodeficiency virus (HIV)‐positive patients may be potential organ donors to HIV‐positive recipients in a few countries. Organ shortage remains a challenge for organ transplantation in Taiwan, where organ donation by HIV‐positive patients remains prohibited by law. Methods...

article

DeF-GPU: Efficient and effective deletions finding in hepatitis B viral genomic DNA using a GPU architecture

Chun-Pei Cheng, Kuo-Lun Lan, Wen-Chun Liu, Ting-Tsung Chang, more

Methods > 2016 > 111 > C > 56-63

Hepatitis B viral (HBV) infection is strongly associated with an increased risk of liver diseases like cirrhosis or hepatocellular carcinoma (HCC). Many lines of evidence suggest that deletions occurring in HBV genomic DNA are highly associated with the activity of HBV via the interplay between aberrant viral proteins release and human immune system. Deletions finding on the HBV whole genome sequences...

article

Risk of recurrent nontyphoid Salmonella bacteremia in human immunodeficiency virus-infected patients with short-term secondary prophylaxis in the era of combination antiretroviral therapy

Yu-Ju Chou, Hui-Wen Lin, Chia-Jui Yang, Mao-Yuan Chen, more

Journal of Microbiology, Immunology and Infection > 2016 > 49 > 5 > 760-767

Nontyphoid Salmonella (NTS) bacteremia causes high mortality and recurrence rates in human immunodeficiency virus (HIV)-infected patients. This study aimed to investigate the risk of recurrent NTS bacteremia in the era of combination antiretroviral therapy (cART).The medical records of consecutive HIV-infected patients with NTS bacteremia from January 2006 to June 2014 were reviewed. The patients...

article

Multi-subtype influenza virus-like particles incorporated with flagellin and granulocyte-macrophage colony-stimulating factor for vaccine design

Wen-Chun Liu, Ying-Yu Liu, Ting-Hsuan Chen, Chia-Chyi Liu, more

Antiviral Research > 2016 > 133 > C > 110-118

Virus-like particle (VLP) technology is an attractive platform for seasonal and pandemic influenza vaccine development. We previously showed that influenza VLPs can be modified using M2 fusion with molecular adjuvants such as Salmonella typhimurium flagellin (FliC) to enhance VLP immunogenicity. For this study, three types of chimeric VLPs were incorporated with FliC, granulocyte-macrophage colony-stimulating...

article

Development of single-chain variable fragments (scFv) against influenza virus targeting hemagglutinin subunit 2 (HA2)

Tai-Wei Li, Shu-Fang Cheng, Yen-Tzu Tseng, Yu-Chih Yang, more

Archives of Virology > 2016 > 161 > 1 > 19-31

Influenza A viruses (IAV) are widespread in birds and domestic poultry, occasionally causing severe epidemics in humans and posing health threats. Hence, the need to develop a strategy for prophylaxis or therapy, such as a broadly neutralizing antibody against IAV, is urgent. In this study, single-chain variable fragment (scFv) phage display technology was used to select scFv fragments recognizing...

article

Aligning to the sample-specific reference sequence to optimize the accuracy of next-generation sequencing analysis for hepatitis B virus

Wen-Chun Liu, Chih-Peng Lin, Chun-Pei Cheng, Cheng-Hsun Ho, more

Hepatology International > 2016 > 10 > 1 > 147-157

Background Hepatitis B virus (HBV) quasispecies are crucial in the pathogenesis of chronic liver disease. Next-generation sequencing (NGS) is powerful for identifying viral quasispecies. To improve mapping quality and single nucleotide variant (SNV) calling accuracy in the NGS analysis of HBV, we compared different mapping references, including the sample-specific reference sequence, same genotype...

article

In vivo Merkmale der Fox‐Fordyce‐Krankheit in der hochauflösenden optischen Kohärenztomographie

Wen Chun Liu, Taige Cao, Madeline Sheun Ling Ho, Wei‐Sheng Chong, more

JDDG: Journal der Deutschen Dermatologischen Gesellschaft > 14 > 1 > 62 - 63

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INFONA - science communication portal

Search results for: Wen-Chun Liu

Evolution of estimated glomerular filtration rate in human immunodeficiency virus and hepatitis C virus‐coinfected patients receiving sofosbuvir‐based direct‐acting antivirals and antiretroviral therapy

Hepatitis E Virus Infections Among Human Immunodeficiency Virus–Positive Individuals During an Outbreak of Acute Hepatitis A in Taiwan

HCV reinfections after viral clearance among HIV‐positive patients with recent HCV infection in Taiwan

Long-term virological and serologic responses of chronic hepatitis B virus infection to tenofovir disoproxil fumarate-containing regimens in patients with HIV and hepatitis B coinfection

Glycan‐masking hemagglutinin antigens from stable CHO cell clones for H5N1 avian influenza vaccine development

Serological responses to revaccination against HBV in HIV‐positive patients born in the era of nationwide neonatal HBV vaccination

Serological responses to revaccination with hepatitis A virus (HAV) vaccines among HIV‐positive individuals whose anti‐HAV antibody waned after primary vaccination

Applications of next-generation sequencing analysis for the detection of hepatocellular carcinoma-associated hepatitis B virus mutations

Incidence of acute hepatitis A among HIV‐positive patients during an outbreak among MSM in Taiwan: Impact of HAV vaccination

Treatment response to unboosted atazanavir in combination with tenofovir disoproxil fumarate and lamivudine in human immunodeficiency virus-1-infected patients who have achieved virological suppression: A therapeutic drug monitoring and pharmacogenetic study

Detecting exact breakpoints of deletions with diversity in hepatitis B viral genomic DNA from next-generation sequencing data

Hepatocellular carcinoma‐associated single‐nucleotide variants and deletions identified by the use of genome‐wide high‐throughput analysis of hepatitis B virus

d:x reflectance measurement for curved surface with integrating sphere

Willingness of human immunodeficiency virus‐positive patients to donate their organs for transplantation in Taiwan: a cross‐sectional questionnaire survey

DeF-GPU: Efficient and effective deletions finding in hepatitis B viral genomic DNA using a GPU architecture

Risk of recurrent nontyphoid Salmonella bacteremia in human immunodeficiency virus-infected patients with short-term secondary prophylaxis in the era of combination antiretroviral therapy

Multi-subtype influenza virus-like particles incorporated with flagellin and granulocyte-macrophage colony-stimulating factor for vaccine design

Development of single-chain variable fragments (scFv) against influenza virus targeting hemagglutinin subunit 2 (HA2)

Aligning to the sample-specific reference sequence to optimize the accuracy of next-generation sequencing analysis for hepatitis B virus

In vivo Merkmale der Fox‐Fordyce‐Krankheit in der hochauflösenden optischen Kohärenztomographie

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