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Two recombinant adenoviruses were constructed expressing foot-and-mouth disease virus (FMDV) capsid and 3C/3CD proteins in replicative deficient human adenovirus type 5 vector. Guinea pigs vaccinated with 1–3×10 8 TCID 50 Ad-P12×3C recombinant adenovirus were completely protected against 10,000GID 50 homologous virulent FMDV challenge 25 days post vaccination (dpv). Ad-P12×3CD...
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