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Multiple sequence alignment is the most common task in computational biology. This multiple sequence alignment is computationally difficult and classified as a NP-Hard problem; so approximate algorithm(s) are generally required for most multiple alignment tasks. The Molecular Biologist may require the alignment of thousands of sequences that each can be of many hundreds of amino acids or even several...
In this paper we propose a novel method for splice site prediction using the maximum likelihood model. We performed maximum likelihood over the acceptor and donor datasets, and calculated sensitivity to measure the prediction performance. Then, by aggressive pruning of less informative nucleotide sites, while maintaining the high sensitivity of the method, we improved the model's performance in terms...
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