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Prevention of recurrent hepatitis C virus (HCV) infection after liver transplantation is a major unmet clinical need. ITX5061 is a small molecule antagonist of scavenger receptor B-I that prevents HCV entry and infection in vitro. The aim of this phase 1 study was to determine safety and efficacy of ITX5061 to prevent HCV allograft infection. In this phase 1b single-centre, prospective, open-label...
After liver transplantation in patients infected with hepatitis C virus (HCV), reinfection of the transplanted liver is universal. The targeting of viral entry at the time of transplantation is therefore an attractive strategy. An understanding of the mechanisms and kinetics of this process will allow rational studies of small molecule inhibitors or neutralising antibodies that target HCV entry. ...
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