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To investigate the effect of a high‐fat diet and aerobic exercise intervention and its related mechanism on rat germ cell apoptosis. Forty male Sprague‐Dawley rats were randomly divided into control group, high‐fat diet group, control exercise group and high‐fat exercise group. Rats were fed with high‐fat diet or were given weight‐free swimming. The levels of TG, TC, HDL, LDL and IL‐6 in serum of...
Diabetic erectile dysfunction (ED) is a common complication in diabetes mellitus, and the efficacy of first‐line therapies is not satisfactory. Recent studies revealed that corporal apoptosis was responsible for the nonresponsiveness of severe ED to phosphodiesterase type 5 inhibitors. Mitofusin 2 (Mfn2) is a versatile protein, regulating mitochondrial morphology and playing an important role in apoptosis...
HAP (a homologue of the ASY/Nogo-B protein), a novel human apoptosis-inducing protein, was found to be identical to RTN3. In an earlier study, we demonstrated that HAP localized exclusively to the endoplasmic reticulum (ER) and that its overexpression could induce cell apoptosis via a depletion of endoplasmic reticulum (ER) Ca2+ stores. In this study, we show that overexpression of HAP causes the...
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