Search results for: Hans-Gustaf Ljunggren

Items from 1 to 20 out of 77 results

article

Viral escape from NK‐cell‐mediated immunosurveillance: A lesson for cancer immunotherapy?

Pouria Momayyezi, Eleni Bilev, Hans‐Gustaf Ljunggren, Quirin Hammer

European Journal of Immunology > 53 > 11 > n/a - n/a

Natural killer (NK) cells are innate lymphocytes that participate in immune responses against virus‐infected cells and tumors. As a countermeasure, viruses and tumors employ strategies to evade NK‐cell‐mediated immunosurveillance. In this review, we examine immune evasion strategies employed by viruses, focusing on examples from human CMV and severe acute respiratory syndrome coronavirus 2. We explore...

article

SARS‐CoV‐2 antibody titers at the time of hospital admission and risk for mortality

Hans‐Gustaf Ljunggren

Journal of Internal Medicine > 293 > 6 > 664 - 665

article

Nobel 2022: An extraordinary achievement relevant to immunity

Petter Höglund, Hans‐Gustaf Ljunggren, Roland Jonsson

Scandinavian Journal of Immunology > 96 > 6 > n/a - n/a

article

The Karolinska KI/K COVID‐19 immune atlas: An open resource for immunological research and educational purposes

Hans‐Gustaf Ljunggren, Eivind Heggernes Ask, Martin Cornillet, Benedikt Strunz, more

Scandinavian Journal of Immunology > 96 > 1 > n/a - n/a

The Karolinska KI/K COVID‐19 Immune Atlas project was conceptualized in March 2020 as a part of the academic research response to the developing SARS‐CoV‐2 pandemic. The aim was to rapidly provide a curated dataset covering the acute immune response towards SARS‐CoV‐2 infection in humans, as it occurred during the first wave. The Immune Atlas was built as an open resource for broad research and educational...

article

COVID‐19‐specific metabolic imprint yields insights into multiorgan system perturbations

Martin Cornillet, Benedikt Strunz, Olav Rooyackers, Andrea Ponzetta, more

European Journal of Immunology > 52 > 3 > 503 - 510

Corona disease 2019 (COVID‐19) affects multiple organ systems. Recent studies have indicated perturbations in the circulating metabolome linked to COVID‐19 severity. However, several questions pertain with respect to the metabolome in COVID‐19. We performed an in‐depth assessment of 1129 unique metabolites in 27 hospitalized COVID‐19 patients and integrated results with large‐scale proteomic and immunology...

article

Jacob B. Natvig (1934‐2021), one of the founders of Scandinavian Journal of Immunology

Roland Jonsson, Hans‐Gustaf Ljunggren, Hans Wigzell, Stig Sophus Frøland, more

Scandinavian Journal of Immunology > 94 > 1 > n/a - n/a

article

Paths taken towards NK cell–mediated immunotherapy of human cancer—a personal reflection

Hans‐Gustaf Ljunggren

Scandinavian Journal of Immunology > 93 > 1 > n/a - n/a

The discovery that NK cells are able to specifically recognize cells lacking the expression of self‐MHC class I molecules provided the first insight into NK cell recognition of tumour cells. It started a flourishing field of NK cell research aimed at exploring the molecular nature of NK cell receptors involved in tumour cell recognition. While much of the important early work was conducted in murine...

article

Covid‐19, SSI 50 years and Nobel: Three immunological reasons to remember 2020

Petter Höglund, Hans‐Gustaf Ljunggren, Roland Jonsson

Scandinavian Journal of Immunology > 92 > 6 > n/a - n/a

article

Outcome of COVID‐19 in multiple myeloma patients in relation to treatment

Katharina Helene Susek, Charlotte Gran, Hans‐Gustaf Ljunggren, Evren Alici, more

European Journal of Haematology > 105 > 6 > 751 - 754

COVID‐19 has emerged as a global pandemic. Cancer patients have been reported to be at higher risk for adverse outcome of COVID‐19. Studies are ongoing to decipher the risk factors and risk groups among cancer patients as well as strategies to refine treatment approaches. Here, we report eight patients with multiple myeloma that underwent immunomodulatory therapies with daratumumab or lenalidomide‐based...

article

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Andrea Cossarizza, Hyun‐Dong Chang, Andreas Radbruch, Andreas Acs, more

European Journal of Immunology > 49 > 10 > 1457 - 1973

These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry community. They provide the theory and key practical aspects of flow cytometry enabling immunologists to avoid the common errors that often undermine immunological data. Notably, there are comprehensive sections of all major immune cell types with helpful Tables detailing phenotypes in murine...

article

Seminal immunologic discoveries with direct clinical implications: The 2018 Nobel Prize in Physiology or Medicine honours discoveries in cancer immunotherapy

Hans‐Gustaf Ljunggren, Roland Jonsson, Petter Höglund

Scandinavian Journal of Immunology > 88 > 6 > n/a - n/a

article

Proteome analysis of human CD56^neg NK cells reveals a homogeneous phenotype surprisingly similar to CD56^dim NK cells

Jenny Voigt, David F.G. Malone, Joana Dias, Edwin Leeansyah, more

European Journal of Immunology > 48 > 9 > 1456 - 1469

NK cells lacking CD56 (CD56^neg) were first identified in chronic HIV‐1 infection. However, CD56^neg NK cells also exist in healthy individuals, albeit in significantly lower numbers. Here, we provide an extensive proteomic characterisation of human CD56^neg peripheral blood NK cells of healthy donors and compare them to their CD56^dim and CD56^bright counterparts. Unbiased large‐scale surface receptor...

article

Composition and functionality of the intrahepatic innate lymphoid cell‐compartment in human nonfibrotic and fibrotic livers

Marianne Forkel, Lena Berglin, Eliisa Kekäläinen, Adrian Carlsson, more

European Journal of Immunology > 47 > 8 > 1280 - 1294

Human innate lymphoid cells have been described to exist in different organs, with functional deregulation of these cells contributing to several disease states. Here, we performed the first detailed characterization of the phenotype, tissue‐residency properties, and functionality of ILC1s, ILC2s, and ILC3s in the human adult and fetal liver. In addition, we investigated changes in the ILC compartment...

article

Immune selection during tumor checkpoint inhibition therapy paves way for NK-cell “missing self” recognition

Karl-Johan Malmberg, Ebba Sohlberg, Jodie P. Goodridge, Hans-Gustaf Ljunggren

Immunogenetics > 2017 > 69 > 8-9 > 547-556

The ability of NK cells to specifically recognize cells lacking expression of self-MHC class I molecules was discovered over 30 years ago. It provided the foundation for the “missing self” hypothesis. Research in the two past decades has contributed to a detailed understanding of the molecular mechanisms that determine the specificity and strength of NK cell-mediated “missing self” responses to tumor...

article

Contribution of inhibitory receptor TIGIT to NK cell education

Yuke He, Hui Peng, Rui Sun, Haiming Wei, more

Journal of Autoimmunity > 2017 > 81 > C > 1-12

Engagement of inhibitory receptors by cognate host MHC-I molecules triggers NK cell education, resulting in functional maturation and allowing NK cells to sense missing-self. However, NK cells also express inhibitory receptors for non-MHC-I ligands and their role in NK cell education is poorly understood. TIGIT is a recently identified inhibitory receptor that recognizes a non-MHC-I ligand CD155....

article

Reply

Nicole Marquardt, Hans-Gustaf Ljunggren, Jakob Michaëlsson

Journal of Allergy and Clinical Immunology > 2017 > 140 > 1 > 318

article

Natural killer cell-mediated immunosurveillance of human cancer

Karl-Johan Malmberg, Mattias Carlsten, Andreas Björklund, Ebba Sohlberg, more

Seminars in Immunology > 2017 > 31 > C > 20-29

The contribution of natural killer (NK) cells to immunosurveillance of human cancer remains debatable. Here, we discuss advances in several areas of human NK cell research, many of which support the ability of NK cells to prevent cancer development and avoid relapse following adoptive immunotherapy. We describe the molecular basis for NK cell recognition of human tumor cells and provide evidence for...

article

Human lung natural killer cells are predominantly comprised of highly differentiated hypofunctional CD69−CD56dim cells

Nicole Marquardt, Eliisa Kekäläinen, Puran Chen, Egle Kvedaraite, more

Journal of Allergy and Clinical Immunology > 2017 > 139 > 4 > 1321-1330.e4

In contrast to the extensive knowledge about human natural killer (NK) cells in peripheral blood, relatively little is known about NK cells in the human lung. Knowledge about the composition, differentiation, and function of human lung NK cells is critical to better understand their role in diseases affecting the lung, including asthma, chronic obstructive pulmonary disease, infections, and cancer...

article

Nonreversible MAIT cell‐dysfunction in chronic hepatitis C virus infection despite successful interferon‐free therapy

Julia Hengst, Benedikt Strunz, Katja Deterding, Hans‐Gustaf Ljunggren, more

European Journal of Immunology > 46 > 9 > 2204 - 2210

Immune exhaustion is a hallmark of chronic viral infections. However, pathogen eradication can result in reinvigorated immune responses. Indeed, this was recently suggested for antigen‐specific CD8⁺ T cells and NK cells in HCV‐infected patients receiving an interferon‐free treatment regimen. Mucosal‐associated invariant T (MAIT) cells are evolutionarily conserved innate‐like effector T cells. Here,...

article

In vivo engineering of mobilized stem cell grafts with the immunomodulatory drug FTY720 for allogeneic transplantation

Tadepally Lakshmikanth, Frank Heuts, S. S. V. Jagadeeswara Rao Muvva, Robert P. A. Wallin, more

European Journal of Immunology > 46 > 7 > 1758 - 1769

The immunological attributes of stem cell grafts play an important role in the outcome of allogeneic stem cell transplants. Currently, ex vivo manipulation techniques such as bulk T‐cell depletion or positive selection of CD34⁺ cells are utilized to improve the immunological attributes of grafts and minimize the potential for graft‐versus‐host disease (GvHD). Here, we demonstrate a novel graft engineering...

Publication date

Last 3 years (5)

Close

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

From:

To:
Set your own date range

INFONA - science communication portal

Search results for: Hans-Gustaf Ljunggren

Viral escape from NK‐cell‐mediated immunosurveillance: A lesson for cancer immunotherapy?

SARS‐CoV‐2 antibody titers at the time of hospital admission and risk for mortality

Nobel 2022: An extraordinary achievement relevant to immunity

The Karolinska KI/K COVID‐19 immune atlas: An open resource for immunological research and educational purposes

COVID‐19‐specific metabolic imprint yields insights into multiorgan system perturbations

Jacob B. Natvig (1934‐2021), one of the founders of Scandinavian Journal of Immunology

Paths taken towards NK cell–mediated immunotherapy of human cancer—a personal reflection

Covid‐19, SSI 50 years and Nobel: Three immunological reasons to remember 2020

Outcome of COVID‐19 in multiple myeloma patients in relation to treatment

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Seminal immunologic discoveries with direct clinical implications: The 2018 Nobel Prize in Physiology or Medicine honours discoveries in cancer immunotherapy

Proteome analysis of human CD56^neg NK cells reveals a homogeneous phenotype surprisingly similar to CD56^dim NK cells

Composition and functionality of the intrahepatic innate lymphoid cell‐compartment in human nonfibrotic and fibrotic livers

Immune selection during tumor checkpoint inhibition therapy paves way for NK-cell “missing self” recognition

Contribution of inhibitory receptor TIGIT to NK cell education

Reply

Natural killer cell-mediated immunosurveillance of human cancer

Human lung natural killer cells are predominantly comprised of highly differentiated hypofunctional CD69−CD56dim cells

Nonreversible MAIT cell‐dysfunction in chronic hepatitis C virus infection despite successful interferon‐free therapy

In vivo engineering of mobilized stem cell grafts with the immunomodulatory drug FTY720 for allogeneic transplantation

Filter options

Publication date

Content availability

Publication type

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Hans-Gustaf Ljunggren

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Content availability

Publication type

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options