Search results for: Victoria Kolb-Bachofen

Items from 1 to 20 out of 38 results

article

Biological effects of nitric oxide generated by an atmospheric pressure gas-plasma on human skin cells

Joerg Liebmann, Joachim Scherer, Nikita Bibinov, Priyadarshini Rajasekaran, more

Nitric Oxide > 2011 > 24 > 1 > 8-16

Physical plasmas which contain a mixture of different radicals, charged species and UV-radiation, have recently found entry in various medical applications. Though first clinical trials are underway nothing is known about the plasma components mediating the biological effects seen and safety concerns have been neglected. We here use for the first time a plasma device equipped with a bent quartz capillary...

article

Photolytically generated nitric oxide inhibits caspase activity and results in AIF-mediated cell death

Joerg Liebmann, Victoria Kolb-Bachofen, Csaba Mahotka, Christoph V. Suschek

Journal of Molecular Medicine > 2010 > 88 > 3 > 279-287

In human skin tissue nitrite is found at relatively high concentrations and represents the main source for cutaneous non-enzymatic nitric oxide (NO) formation during UVA exposure due to photolytical decomposition. Since NO has been repeatedly shown to act pro- as well as anti-apoptotic we here studied the effects of UVA irradiation on human keratinocytes in the presence of nitrite. We show that UVA-induced...

article

Heat shock protein 60: Evidence for receptor-mediated induction of proinflammatory mediators during adipocyte differentiation

Elke Gülden, Tina Märker, Jennifer Kriebel, Victoria Kolb-Bachofen, more

FEBS Letters > 2009 > 583 > 17 > 2877-2881

Adipocytes play important roles in lipid metabolism but also in the control of inflammatory processes. Based on our previous findings of heat shock protein (Hsp) 60-induced activation of preadipocytes we investigated whether the capacity of heat shock protein 60 (Hsp60) to interact with adipocytes and to stimulate their proinflammatory activity is determined by the differentiation state of the cells...

article

A new redox-dependent mechanism of MMP-1 activity control comprising reduced low-molecular-weight thiols and oxidizing radicals

Sabine Koch, Christine M. Volkmar, Victoria Kolb-Bachofen, Hans-Gert Korth, more

Journal of Molecular Medicine > 2009 > 87 > 3 > 261-272

Matrix metalloproteinases (MMPs), a family of zinc-dependent proteinases, participate in remodeling and degradation of the extracellular matrix proteins. The activity of MMPs is thought to be predominately posttranslationally regulated via proteolytic activation of precursor zymogens or via their naturally occurring endogenous inhibitors. Here, using recombinant MMP-1, we investigated new redox-dependent...

article

Zinc protects endothelial cells from hydrogen peroxide via Nrf2-dependent stimulation of glutathione biosynthesis

Miriam M. Cortese, Christoph V. Suschek, Wiebke Wetzel, Klaus-D. Kröncke, more

Free Radical Biology and Medicine > 2008 > 44 > 12 > 2002-2012

Oxidative stress is one of the main causes of vascular disease. This study aims to investigate the antioxidant activity exerted by zinc in primary rat endothelial cells (EC). Using a 24-h treatment with hydrogen peroxide as a model for oxidative stress, we found that zinc supplementation protects from peroxide-induced cell death via increasing the transcription of the catalytic subunit (heavy chain)...

article

O71. NO and epigenetics: New insights into the interplay between iNOS expression and DNA-methylation

Daniela Kremer, Wolfgang Schulz, Victoria Kolb-Bachofen

Nitric Oxide > 2008 > 19 > Supplement > 36

article

O67. Down-regulation of iNOS expression and activity via zinc: A new NO-mediated anti-inflammatory feedback mechanism?

Miriam Margherita Cortese-Krott, Larissa Getinger, Christian Opländer, Victoria Kolb-Bachofen, more

Nitric Oxide > 2008 > 19 > Supplement > 35

article

P95. Blue light at 450nm wavelength modulates proliferation and differentiation of human skin cells

Joerg Liebmann, Matthias Born, Victoria Kolb-Bachofen

Nitric Oxide > 2008 > 19 > Supplement > 65

article

A novel role of interleukin-1-converting enzyme in cytokine-mediated inducible nitric oxide synthase gene expression: Implications for neuroinflammatory diseases

Eric Jüttler, Eckhard Bonmann, Matthias Spranger, Victoria Kolb-Bachofen, more

Molecular and Cellular Neuroscience > 2007 > 34 > 4 > 612-620

Inducible nitric oxide synthase (iNOS)-derived NO plays an important role in several neurological disorders. Understanding of mechanisms involved in the regulation of iNOS induction is of particular interest. Here, we investigated mechanisms of iNOS induction in rat astrocytes (AC) and in brain endothelial cells (BEC). We find that activation of AC or BEC with pro-inflammatory cytokines reveals a...

article

In hepatocytes the regulation of NOS-2 activity at physiological l-arginine levels suggests a close link to the urea cycle

Guido Lerzynski, Christoph V. Suschek, Victoria Kolb-Bachofen

Nitric Oxide > 2006 > 14 > 4 > 300-308

High-output synthesis of nitric oxide (NO) by the inducible isoform of NO-synthases (NOS-2) plays an important role in hepatic pathophysiological processes and may contribute to both organ protection and organ destruction during inflammatory reactions. As they compete for the same substrate, l-arginine, an interdependence of NOS-2 and arginase-1 has been repeatedly observed in cells where arginase-1...

article

O42. Nitrite and nitrosothiol-derived NO is an important physiological signal during UV-irradiation in human skin

Jörg Liebmann, Adnana Paunel-Görgülü, Victoria Kolb-Bachofen, Christoph V. Suschek

Nitric Oxide > 2006 > 14 > 4 > 13

article

O24. Increased NOS2 expression following DNA demethylation: A double-edged sword!

Daniela Kremer, Wolfgang Schulz, Victoria Kolb-Bachofen

Nitric Oxide > 2006 > 14 > 4 > 7-8

article

O40. Nitric oxide signalling leading to altered gene expression and oxidative stress resistance involves a zinc-dependent activation of transcription factors nrf-2 and MTF-1

Miriam M. Cortese, Christoph V. Suschek, Victoria Kolb-Bachofen

Nitric Oxide > 2006 > 14 > 4 > 12-13

article

Effects of acute stress on local IL-1β and IL-8 in a human in vivo model of chronic inflammation

Ulrike Weik, Kirsten Schwebke, Nicole Granrath, Victoria Kolb-Bachofen, more

Brain Behavior and Immunity > 2006 > 20 > 3 Supplement > 75-76

article

What sense lies in antisense inhibition of inducible nitric oxide synthase expression?

Karsten Hemmrich, Klaus-D. Kröncke, Christoph V. Suschek, Victoria Kolb-Bachofen

Nitric Oxide > 2005 > 12 > 4 > 183-199

The impact of nitric oxide (NO) synthesized after activation by proinflammatory cytokines and/or bacterial products by an inducible NO synthase (iNOS) is still contradictory. Expression of iNOS in inflammatory reactions is often found predominantly in cells of epithelial origin, and in these cases NO may serve as a protective agent limiting pathogen spreading, downregulating local inflammatory reactions...

article

Arginase-1 overexpression induces cationic amino acid transporter-1 in psoriasis

Oliver Schnorr, Maximilian Schuier, Guido Kagemann, Ronald Wolf, more

Free Radical Biology and Medicine > 2005 > 38 > 8 > 1073-1079

Regulated uptake of extracellular l-arginine by cationic amino acid transporters (CATs) is required for inducible nitric oxide synthase and arginase activity. Both enzymes were recently recognized as important in the pathophysiology of psoriasis because of their contribution to epidermal hyperproliferation. We here characterize the expression pattern of CATs in psoriatic skin compared to healthy skin...

article

Enzyme-independent nitric oxide formation during UVA challenge of human skin: characterization, molecular sources, and mechanisms

Adnana N. Paunel, André Dejam, Sven Thelen, Michael Kirsch, more

Free Radical Biology and Medicine > 2005 > 38 > 5 > 606-615

Many of the local UV-induced responses including erythema and edema formation, inflammation, premature aging, and immune suppression can be influenced by nitric oxide synthase (NOS)-produced NO which is known to play a pivotal role in cutaneous physiology. Besides NOS-mediated NO production, UV radiation might trigger an enzyme-independent NO formation in human skin by a mechanism comprising the decomposition...

article

Explaining Decreased Nitric Oxide Production in Psoriatic Lesions: Arginase 1 Overexpression versus Calcitonin Gene-Related Peptide

Mohammad Reza Namazi, Victoria Kolb-Bachofen

The American Journal of Pathology > 2003 > 163 > 6 > 2642-2643

article

Limitation of Inducible Nitric Oxide Synthase Activity as a Molecular Mechanism for Keratinocyte Hyperproliferation

Daniela Bruch-Gerharz, Oliver Schnorr, Christoph Suschek, Karl-Friedrich Beck, more

The American Journal of Pathology > 2003 > 162 > 1 > 203-211

Abnormal proliferation of keratinocytes in the skin appears crucial to the pathogenesis of psoriasis, but the underlying mechanisms remain unknown. Nitric oxide (NO), released from keratinocytes at high concentrations, is considered a key inhibitor of cellular proliferation and inducer of differentiation in vitro. Although high-output NO synthesis is suggested by the expression of inducible NO synthase...

article

Nitric Oxide Inhibits Endothelial IL-1β-induced ICAM-1 Gene Expression at the Transcriptional Level Decreasing Sp1 and AP-1 Activity

Denise Berendji-Grün, Victoria Kolb-Bachofen, Klaus-Dietrich Kröncke

Molecular Medicine > 2001 > 7 > 11 > 748-754

Background Nitric oxide (NO) has frequently been shown to inhibit leukocyte adherence to activated endothelium thus displaying anti-adhesive and immunosuppressive activities. A molecular mechanism contributing to this effect is described. Materials and Methods Primary murine aortic endothelial cells were activated with interleukin (IL)-1β to express intercellular adhesion molecule-1 (ICAM-1) mRNA...

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Search results for: Victoria Kolb-Bachofen

Biological effects of nitric oxide generated by an atmospheric pressure gas-plasma on human skin cells

Photolytically generated nitric oxide inhibits caspase activity and results in AIF-mediated cell death

Heat shock protein 60: Evidence for receptor-mediated induction of proinflammatory mediators during adipocyte differentiation

A new redox-dependent mechanism of MMP-1 activity control comprising reduced low-molecular-weight thiols and oxidizing radicals

Zinc protects endothelial cells from hydrogen peroxide via Nrf2-dependent stimulation of glutathione biosynthesis

O71. NO and epigenetics: New insights into the interplay between iNOS expression and DNA-methylation

O67. Down-regulation of iNOS expression and activity via zinc: A new NO-mediated anti-inflammatory feedback mechanism?

P95. Blue light at 450nm wavelength modulates proliferation and differentiation of human skin cells

A novel role of interleukin-1-converting enzyme in cytokine-mediated inducible nitric oxide synthase gene expression: Implications for neuroinflammatory diseases

In hepatocytes the regulation of NOS-2 activity at physiological l-arginine levels suggests a close link to the urea cycle

O42. Nitrite and nitrosothiol-derived NO is an important physiological signal during UV-irradiation in human skin

O24. Increased NOS2 expression following DNA demethylation: A double-edged sword!

O40. Nitric oxide signalling leading to altered gene expression and oxidative stress resistance involves a zinc-dependent activation of transcription factors nrf-2 and MTF-1

Effects of acute stress on local IL-1β and IL-8 in a human in vivo model of chronic inflammation

What sense lies in antisense inhibition of inducible nitric oxide synthase expression?

Arginase-1 overexpression induces cationic amino acid transporter-1 in psoriasis

Enzyme-independent nitric oxide formation during UVA challenge of human skin: characterization, molecular sources, and mechanisms

Explaining Decreased Nitric Oxide Production in Psoriatic Lesions: Arginase 1 Overexpression versus Calcitonin Gene-Related Peptide

Limitation of Inducible Nitric Oxide Synthase Activity as a Molecular Mechanism for Keratinocyte Hyperproliferation

Nitric Oxide Inhibits Endothelial IL-1β-induced ICAM-1 Gene Expression at the Transcriptional Level Decreasing Sp1 and AP-1 Activity

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