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Pinpointing the sources of dementia is crucial to the effective treatment of neurodegenerative diseases. In this paper, we propose a diffusion model with impulsive sources over the brain connectivity network to model the progression of brain atrophy. To reliably estimate the atrophy sources, we impose sparse regularization on the source distribution and solve the inverse problem with an efficient...
The Alzheimer's Disease Neuroimaging Initiative (ADNI) employed phantom-based scaling of T1-weighted MP-RAGE brain images to improve spatial calibration of scans and longitudinal stability across study sites. Early in ADNI, errors in phantom based scaling were identified due to incorrect acquisition protocols or replacement of phantoms. Images initially made available with questionable scaling factors...
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