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Abstract. Rationale: There is good evidence that 3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity results from free radical formation. However, it is unclear whether it is the presence of MDMA or a metabolite in the brain that initiates this process. Objective: We wished to measure the concentration of MDMA in the brain following peripheral administration of neurotoxic doses and examine...
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