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The effect of continuous intrathecal infusion of ω-conopeptides in the rat was examined to determine whether antinociception, as measured on the formalin and hot-plate (52.5°C) tests, was altered and whether tolerance developed with chronic infusion of these agents. Infusion of 0.030 and 0.003 nmol/h SNX-111 and 0.290 nmol/h SNX-239 was performed for either 2 days ( acute ) or 7 days ( chronic...
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