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Therapeutic development in amyotrophic lateral sclerosis (ALS) is hampered by the lack of suitable biomarkers that might be sensitive to spatial and temporal patterns of neurodegeneration. Diffusion tensor imaging is a useful non-invasive tool that permits detection of microstructural tissue changes due, for example, to neurodegeneration. Even though the spinal cord bears the brunt of the disease...
Objective: To investigate changes in the diffusion tensor imaging measures, axial diffusivity and radial diffusivity, in addition to the more commonly used fractional anisotropy and mean diffusivity, in patients with amyotrophic lateral sclerosis (ALS) using the voxel-based statistical analysis tool, tract based spatial statistics. Methods: We studied 12 patients with ALS and 19 normal controls using...
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