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Intracellular protein degradation is essential for the survival of all organisms, but its role in interspecies interaction is unknown. Here, we show that the ClpXP protease of Pseudomonas aeruginosa suppresses its antimicrobial activity against Staphylococcus aureus, a common pathogen co‐isolated with P. aeruginosa from polymicrobial human infections. Using proteomic, biochemical, and molecular genetic...
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