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DOI: 10.1002/pmic.201900325
Identifying the target proteins of bioactive small molecules is a key step in understanding the mode‐of‐action of a drug and addressing the underlying mechanisms responsible for a particular phenotype. In article number 1900325 by Hui‐Yun Hwang et al., a robust method utilizing drug affinity responsive target stability (DARTS) and liquid chromatography/tandem mass spectrometry...
Identifying the target proteins of bioactive small molecules is a key step in understanding mode‐of‐action of the drug and addressing the underlying mechanisms responsible for a particular phenotype. Proteomics has been successfully used to elucidate the target protein profiles of unmodified and ligand‐modified bioactive small molecules. In the latter approach, compounds can be modified via click...
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