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Obesity is a chronic disease that affects more than 650 million adults worldwide. Obesity not only is a significant health concern on its own, but predisposes to cardiometabolic comorbidities, including coronary heart disease, dyslipidemia, hypertension, type 2 diabetes, and some cancers. Lifestyle interventions effectively promote weight loss of 5% to 10%, and pharmacological and surgical interventions...
Physiological adaptations to intentional weight loss can facilitate weight regain. This review summarizes emerging findings on hypothalamic and brainstem circuitry in the regulation of body weight and identifies promising areas for research to improve therapeutic interventions for sustainable weight loss. There is good evidence that body weight is actively regulated in a homeostatic fashion similar...
Objective
To quantify the feedback control of energy intake in response to long‐term covert manipulation of energy balance in free‐living humans.
Methods
A validated mathematical method was used to calculate energy intake changes during a 52‐week placebo‐controlled trial in 153 patients treated with canagliflozin, a sodium glucose co‐transporter inhibitor that increases urinary glucose excretion,...
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