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Acyclovir is a well‐known antiviral agent. It can be administered in very high doses (from 200 to 1000 mg even three–four times daily). It has absorption problems mainly due to its poor solubility in water (about 0.2 g/100 mL at 25°C) and its oral bioavailability is approximately 15%–20% with a half‐life of about 3 h. To improve acyclovir solubility and/or its dissolution properties, two cocrystals...
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