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Ectopic orofacial pain develops with local inflammation in remote orofacial structures. However, the mechanism underlying the spreading of pain to remote orofacial areas after local inflammation is still unknown. We investigated the functional significance of neural communication within the trigeminal ganglion (TG) via nerve growth factor (NGF) or calcitonin gene-related peptide (CGRP) in relation...
Ectopic pain in other orofacial regions develops with local inflammation in separated orofacial structures. However, the basis for the spreading of pain to adjacent orofacial areas after local inflammation is still unknown. In the present study, we determined if the P2X 3 receptor (P2X 3 R) was associated with altered mechanical sensitivity of the whisker pad skin following complete...
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