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Sodium Magnetic Resonance Imaging (MRI) is an attractive imaging technique for early detection of osteoarthritis, as sodium concentrations correlate with proteoglycan content. However sodium yields much less signal in human tissues compared to hydrogen: it has a very rapid transverse signal decay (T2) and rapid longitudinal relaxation (T1), low gyromagnetic ratio and much smaller concentration than...
The theory and application of magnetic resonance imaging (MRI) pulse sequences following the administration of an exogenous contrast agent are discussed. Pulse sequences are categorised according to the contrast agent mechanism: changes in proton density, relaxivity, magnetic susceptibility and resonant frequency shift. Applications in morphological imaging, magnetic resonance angiography, dynamic...
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